MP010
Novel strategy to reshape an immunosuppressive TME barrier innovative mechanism with novel combination of targets
Tumor Microenvironment (TME)
- Tumors create an immunosuppressive TME that blocks immune activation and builds ECM wall.
- Fibroblasts and MSCs alter their shape and behavior, secreting higher levels of growth factors, cytokines, and chemokines.
- As a result, the tumor stroma creates a supportive environment that promotes cancer progression and metastasis1)


- EDB-FN, a protein modulates extracellular matrix stiffness, hindering targeted delivery to the tumor.
- TGF-β plays a crucial role in the regulation of the tumor microenvironment, promoting cancer proliferation and progression.